Create Flexo color profile

Hello all, can anyone give me a shade of light here please, I have to create color profile on a flexo machine my questions are:

1) Substrate: PET / PE / VMPET (Metalized PET)?
2) With white underlay?
3) Number of colors?
4) Print Process Finish? Reverse Print / Direct Print
5) With lamination? PE Laminated / VMPET Laminated

Above all listed, is this possible to create color profile on film/PET substrate?
Please I need feedback on this very badly.

Thanks in advance.